From the North or South via the A2 motorway
On the A2, Castro Verde exit, take the EN 123, at the intersection with the EN 122, turn right towards Mértola (38 km).
From the North via Beja, on the IP2
In Beja, take the IP2 towards Castro Verde, at the junction with the EN 122, turn left towards Mértola (51 km).
From the North via Beja, on the IP8
In Beja, take the IP8 towards Spain, at the junction with the EN 265, turn right towards Serpa. Continue along the EN 265 until you reach Mértola. You enter the municipality through the parish of Santana de Cambas (86 km).
Via the EN 267 towards Mértola (38 km).
From the South (Faro)
On the Via do Infante heading towards Spain, at the Castro Marim exit, take the IC 27 left towards Beja/Mértola, then take the EN 122 and follow it until you reach Mértola (130 km).